Long telomeres and cancer risk among 95 568 individuals from the general population
نویسندگان
چکیده
منابع مشابه
Peripheral blood leukocyte telomere length and mortality among 64,637 individuals from the general population.
BACKGROUND Short telomeres in peripheral blood leukocytes are associated with older age and age-related diseases. We tested the hypotheses that short telomeres are associated with both increased cancer mortality and all-cause mortality. METHODS Individuals (n = 64637) were recruited from 1991 onwards from two Danish prospective cohort studies: the Copenhagen City Heart Study and the Copenhage...
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BACKGROUND The present study aimed to provide information on awareness of the attributable fraction of cancer causes among the Japanese general population. METHODS A nationwide representative sample of 2,000 Japanese aged 20 or older was asked about their perception and level of concern about various environmental and genetic risk factors in relation to cancer prevention, as a part of an Omni...
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Background: TP53 and the oncogene WRAP53 are adjoining genes, producing p53-WRAP53α sense-antisense RNA couples. WRAP53α is indispensable for p53 mRNA regulation and p53 induction following DNA damage. Up-regulated WRAP53β can induce neoplastic transformation and cancer cell survival. All these, along with the associations of WRAP53 single nu...
متن کاملComparison of methods to identify individuals at increased risk of coronary disease from the general population.
OBJECTIVES To evaluate the guidelines on measurement of cholesterol in the national service framework for coronary heart disease and to compare alternative strategies for identifying people at high risk of coronary disease in the general population. DESIGN Comparison of methods (national service framework criteria, Sheffield tables, age threshold of 50 years, estimated risk assessment using f...
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چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...
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ژورنال
عنوان ژورنال: International Journal of Epidemiology
سال: 2016
ISSN: 0300-5771,1464-3685
DOI: 10.1093/ije/dyw179